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Electron micrograph of a group of bacteria coli bacteria It was magnified a hundred thousand times. Each roller is an individual. / Wikipedia
magazine Science A study is published this week showing the pioneering development of a synthetic strain of coli bacteria So that it is “virtually invincible” to viral infection.
With this, the authors showed that efficient production of proteins not found in nature is possible.
researchers from Medical Research Council Cambridge (UK), by genetic engineering, a which contained many non-standard amino acids. In this way, they obtained synthetic bacteria .
CurrencyPublished this week in the magazine ScienceHe is one of the first to design proteins using multiple proteins rather than a single protein (ncAA), that is, hundreds of molecules that can be found in nature or in a laboratory but are not innately used by living organisms.
The authors genetically engineered a synthetic strain of E. coli that included several non-standard amino acids. In this way, they were able to protect the synthetic bacteria from viral infection.
“The ability to create proteins designed using multiple unnatural ‘building blocks’ will open myriad applications, ranging from developing Until with innovative characteristics,” they write In a related article.
In order to understand each other, in nature biological systems are used تستخدم Each is a chain of three nucleotides of DNA or RNA corresponding to a specific amino acid – to code for protein synthesis.
However, there are 64 different twins and there are only Or different natural types, so different codons specify the same amino acids. This is called degeneration .
Experts believe that removing some codons and transferring the RNAs they read from the genome, replacing them with ncAA amino acids, may allow the formation of synthetic cells with characteristics not found in biology, such as and increase the biosynthesis of new proteins.
However, although hundreds of different ncAAs have been genetically encoded in various walks of life, the focus to date has been largely limited to incorporation of a single non-canonical amino acid into the peptide.
.’s new job Science Shows how different types of ncAAs can be incorporated into proteins using a synthetic strain of سلالة coli bacteria. Thus, leading a team He removed the transfer RNA and released factor 1 and cells from this bacterium did not read many codons.
Therefore, since viruses depend on the ability of the host cell to read all the codes of the viral genome to replicate, cells of the host cell coli bacteria Edit became .
The Cambridge specialists reassigned each of these codons to three different types of ncAAs and showed that “the efficient synthesis of tailored proteins is indeed feasible.”
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