Kaepernick will appear in the series and add his own voice to the project.
The limited series will run for six episodes and will reunite DuVernay with Michael Starrbury, who will write and serve as executive producer.
DuVernay and Starrbury previously worked together on “When They See Us,” which received 16 Emmy nominations.
Kaepernick made national news in 2016 when he refused to run two years ago because the national anthem was played before NFL games. He said he did it to protest the police shootings of African-American men and other social injustices faced by black people in the United States.
She added: “Colin’s story has a lot to say about identity, sport and the enduring spirit of protest and resilience. I couldn’t be happier than telling this story with the team on Netflix.”
Netflix has yet to announce the official release date of the series.