In a statement to CNN, his family said that Lander died on Friday at Cedars-Sinai Medical Center after fighting multiple sclerosis for decades.
“David’s family hopes his fans will remember him for all the laughter he has brought into the world.” Read the statement.
In “Laverne & Shirley,” Lander played Squiggy and Michael McKean played Lenny, the upstairs neighbors of Laverne DeFazio and Shirley Feeney, played by Penny Marshall and Cindy Williams, respectively.
Born in Brooklyn, New York, Lander has appeared in 120 movies and TV series including “Who Framed Roger Rabbit”, “Used Cars”, “Scary Movie” and “101 Dalmatians: The Series”.
Lander was diagnosed with multiple sclerosis in 1984, one year after “Laverne & Shirley” ended. He kept the disease a secret until 1999 with the release of his memoir, “Down with Laughter: How Skoyee got MS and didn’t tell anyone.”
He later became known for speaking at conferences, fundraisers, and events where he championed others suffering from multiple sclerosis.
The actor leaves behind his wife, Cathy Lander, who is 41, and daughter, Natalie Lander, who is 37.
CNN’s Holly Silverman contributed to this report.